Loxapinum [Inn-Latin]
Brand names,
Loxapinum [Inn-Latin]
Analogs
Loxapinum [Inn-Latin]
Brand Names Mixture
Loxapinum [Inn-Latin]
Chemical_Formula
C18H18ClN3O
Loxapinum [Inn-Latin]
RX_link
http://www.rxlist.com/cgi/generic2/loxapineoc.htm
Loxapinum [Inn-Latin]
fda sheet
Loxapinum [Inn-Latin]
msds (material safety sheet)
Loxapinum [Inn-Latin]
Synthesis Reference
Neth. pat. Appl. 6,406,089 corresp to Schmutz et al., U.S. pat. 3,546,226 (1964, 1970 both to Wander)
Loxapinum [Inn-Latin]
Molecular Weight
327.808 g/mol
Loxapinum [Inn-Latin]
Melting Point
109-110 oC
Loxapinum [Inn-Latin]
H2O Solubility
No information avaliable
Loxapinum [Inn-Latin]
State
Solid
Loxapinum [Inn-Latin]
LogP
3.162
Loxapinum [Inn-Latin]
Dosage Forms
Tablet; Capsule; Oral solution; IV solution; IM solution
Loxapinum [Inn-Latin]
Indication
For the management of the manifestations of psychotic disorders
Loxapinum [Inn-Latin]
Pharmacology
Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established.
Loxapinum [Inn-Latin]
Absorption
Systemic bioavailability of the parent drug was only about one third that after an equivalent intramuscular dose (25 mg base) in male volunteers
Loxapinum [Inn-Latin]
side effects and Toxicity
LD50=65 mg/kg (Orally in mice)
Loxapinum [Inn-Latin]
Patient Information
Loxapinum [Inn-Latin]
Organisms Affected
Humans and other mammals